XR Brands Intimate Douches & Enemas AF440 Transparent 21 x 5.7 x 5.7 cm
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Colon Hydrotherapy". Aetna IntelliHealth. 1 July 2005. Archived from the original on 7 August 2007 . Retrieved 23 April 2007. Molière (10 May 2018). "?Molière at Versailles". Theater in Translation. The Mercurian . Retrieved 18 July 2020. Recent research has shown that ozone water, which is sometimes used in enemas, can immediately cause microscopic colitis. 
Well documented as having no proven benefits and considered by medical authorities as rash and potentially dangerous is an enema of coffee.   IFRC strongly dissociates from the claim of a 'miracle' solution to defeat malaria" (Press release). International Federation of Red Cross and Red Crescent Societies. 15 May 2013. Archived from the original on 24 February 2021 . Retrieved 24 March 2019.
For children in particular, there may be conflicts of information between the manufacturer’s patient information leaflet (PIL) and guidance provided by GOSH and other healthcare providers. For example, some manufacturers may recommend, in the patient information leaflet, that a medicine is not given to children aged under 12 years. In most cases, this is because the manufacturer will recruit adults to clinical trials in the first instance and therefore the initial marketing authorisation (licence) only covers adults and older children. Nicholls, Pam Hufford; Metules, Terri J (April 2001). "Some old-fashioned enemas still work and are still used". RN. 64: 80.
Paraldehyde is a medicine given to treat seizures or status epilepticus. It works by damping down (suppressing) the nervous system so that a seizure will stop. It has a sedative effect so children usually sleep after it has been given.It is mixed with olive oil so it can be given rectally (into the bottom) as an enema. The enema solution is amber-coloured and has a very strong unpleasant smell. Rectal corticosteroid enemas are sometimes used to treat mild or moderate ulcerative colitis. They also may be used along with systemic (oral or injection) corticosteroids or other medicines to treat severe disease or mild to moderate disease that has spread too far to be treated effectively by medicine inserted into the rectum alone.Another sexual use for enemas is to empty the rectum as a prelude to other anal sexual activities such as anal sex,  possibly reducing risk of infection. In Shakespeare's play Othello (Act II, Scene I) Iago says, "Yet again your fingers to your lips? would they were clyster-pipes for your sake!"